From Evansville:
181 miles, 3 hours 30 min
IN-62 E/E Lloyd Expy 
Exit onto IN-62 E/IN-66 W/US-41 N
Continue to follow US-41 N 
Merge onto US-150 W/US-41 N via the ramp to Terre Haute 
Turn right to merge onto I-70 E toward Indianapolis
Take exit 77 for Holt Rd 
Turn left at S Holt Rd 
Turn right at W Washington St 
Turn left at N White River Pkwy W Dr 
Turn right at W New York St 
Turn left at N University Blvd 
End at 420 N University Blvd. Indianapolis, IN 46202

From Terre Haute:
76 miles, 1 hour 20 min
I-70 E toward Indianapolis
Take exit 77 for Holt Rd 
Turn left at S Holt Rd 
Turn right at W Washington St 
Turn left at N White River Pkwy W
Turn right at W New York St 
Turn left at N University Blvd 
End at 420 N University Blvd. Indianapolis, IN 46202

From Fort Wayne:
127 miles, 2 hours 15 min
I-69 S 
Merge onto I-465 S
Merge onto I-70 W toward Indianapolis
I-69
Take exit 83B to merge onto I-65 N toward Chicago 
Take exit 114 on the left to merge onto N Dr Martin Luther King Jr St toward West St 
Turn right at W Michigan St 
Turn left at N University Blvd 
End at 420 N University Blvd Indianapolis, IN 46202

From South Bend:
138 miles, 3 hours 10 min
US-31 S
Continue on N Meridian St 
Turn right at W 30th St 
Slight left onto the I-65 S ramp 
Keep right at the fork to continue toward I-65 S and merge onto I-65 S 
Take exit 114 to merge onto N Dr Martin Luther King Jr St toward West St 
Turn right at W Michigan St 
Turn left at N University Blvd 
End at 420 N University Blvd Indianapolis, IN 46202

From Richmond:
73 miles, 1 hour 15 min
I-70 W
83B to merge onto I-65 N toward Chicago 
Take exit 114 on the left to merge onto N Dr Martin Luther King Jr St toward West St 
Turn right at W Michigan St 
Turn left at N University Blvd 
End at 420 N University Blvd Indianapolis, IN 46202